Doctors in the Syrian capital treated thousands of patients who were experiencing neurotoxic symptoms, including pinpoint pupils, foaming mouths, convulsions, blurry vision, and difficulty breathing. Last review Dr ÍO11/04/23.In the hours following the reported chemical weapons attack in the suburbs of Damascus last Wednesday, ailing men, women, and children flocked to the city's hospitals. Group 2 = agents to prevent absorption and enhance elimination Įvidence 1 = well documented 2 = widely used, lack of evidence Ĭontent by Dr Íomhar O' Sullivan. Toxicity with isoniazid & ethylene glycol May be considered in the empirical management of toxicity with cyanide due to smoke inhalationĪmanita phalloides (death cap mushrooms) poisoning
Not first line therapy in cases of toxicity with cyanide. Fomepizole is stocked in the antidotes cupboard in the ED at MUH Toxicity with ethylene glycol, may be considered in cases of toxicity with ethanolįomepizole (HSE vs €)is a second line agent after ethanol and haemodialysis for toxicity with ethylene glycol. **Availability A = available immediately B<1 hour C= SupraregionallyĮvidence 1 = well documented 2 = widely used, lack of evidence 3 = questionable usefulnessĪntidotes held in regional holding centres* Agent / drugĭata regarding efficacy in toxicity with arsenic and lead is less convincing. * group 1 = specific antidotes group 2 = agents to prevent absorption and enhance elimination group 3 = other useful agents Injection 2mg/0.2ml, 10mg/ml tablets 10mg Toxicity with coumarin derivatives, including warfarin Toxicity with beta-adrenergic agonists, theophylline Toxicic exposure to organophosphate insecticides Solution for whole bowel irrigation for drug mules ( packers) Patients should have BP & ECG monitored continuously during therapy Penicillamine use should be restricted to cases where other chelating agents are unavailable Toxicity with copper, lead, copper and arsenic poisoning Refractory hypoglycaemia induced by Sulphonylureas & quinnine Injection 400mcg/ml neonatal formulation 40mcg/2ml Opioid poisoning with respiratory and CNS depression unresponsive to supportive therapy To n-acetylcystene but adsorbed by activated charcoal ↓ urothelial toxicity in antineoplastic therapy XS Methotrexate or TrimethoprimĬonsider in toxicity with Ca ++ channel blockers and other agents that cause myocardial depression.
Toxicity with methanol and ethylene glycolĭehydrated alcohol (100% ethanol) 5ml injection Toxicity with arsenic can be used in conjunction with EDTA in cases of severe toxicity with lead, particularly lead encephalopathy More on digoxin toxicity page or Digifab page Tablets 2mg, 5mg, 10mg injection (Diazemuls) 10mg/2ml rectal solution 2.5mg, 5mg, 10mg tubesĬonfirm toxicity by measuring the serum cyanide concentration Mx convulsions, anxiety, agitation and hypertonia 2° to toxins, toxicity with organophosphates ↓t½ and ↑clearance of oral anticoagulants (e.g warfarin) & long acting anticoagulants used as pesticidesĭrug-induced hyperthermia incl. Prevent transdermal adsorption of hydrofluoric acid (HF).Use in cardiac arrest with ALS guidelines Reduction absorption toxic substances by GI tract that are adsorbed by charcoal Link here for the 2008 National Poisons Information Service (NPIS) Antidote booklet or Agent / drug These are the National Poisons Information Service recommended antidotes - May 2009
National poisons information Antidotes Booklet.Īctivated charcoal Atropine Ca ++ gluconate Cholestyramine Cyproheptadine Dantrolene Desferrioxamine Diazepam Dicobalt edetate Digoxin antibodies Dimercaprol Ethanol Flumazenil Folinic acid Fomepizole Glucagon Hydroxocobalamin Isoprenaline Lorazepam Mensa Methionine Methylene blue N-Acetylcysteine Naloxone Neostigmine Octreotide Paraldehyde Penicillamine Phentolamine Phenytoin Polyethylene glycol Pralidoxime Procyclidine Propanolol Protamine sulphate Prussian blue Pyridoxine Na + Ca ++ edetate Sodium nitrite Na + thiosulphate Starch powder Vitamin KĪntidotes held at regional centres DMPS DMSA Fomepizole
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